Research Paper Volume 11, Issue 9 pp 2874—2888

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

Figure 2. Left. Waterfall plots showing the log2 fold chance of circulating BHBA and correlation with treatment outcomes. Right. Violin plots depicting the log2 fold chance of circulating BHBA in each treatment arm categorized by treatment outcomes. (pCR: pathological complete response; QT: chemotherapy; Tzb: trastuzumab; MET: metformin; p-values by Wilcoxon signed-ranked test).