Research Paper Volume 11, Issue 10 pp 3094—3116

Tyrosine nitrations impaired intracellular trafficking of FSHR to the cell surface and FSH-induced Akt-FoxO3a signaling in human granulosa cells

Figure 6. The conserved Y(X)6F(X)6LL motif in the CTs of G protein coupled receptors. The data were constructed from the alignments described in the G protein-coupled receptor database: information system for G protein-coupled receptors (www.gpcrdb.org). Human sequences are shown when available. 5HT1A, human 5-hydroxytryptamine 1A receptor; 5HT1B, human 5-hydroxytryptamine 1B receptor; 5HT1E, human 5-hydroxytryptamine 1E receptor; 5HT4, human 5-hydroxytryptamine 4 receptor; α1B-AR, human α1B adrenergic receptor; α1D-AR, human α1D adrenergic receptor; α2A-AR, human α2A adrenergic receptor; α2B-AR, rat α2B adrenergic receptor; α2C-AR, human α2C adrenergic receptor; α2D-AR, human α2D adrenergic receptor; β1-AR, human β1 adrenergic receptor; β2-AR, human β2 adrenergic receptor; β3-AR, human β3 adrenergic receptor; β4-AR, human β4 adrenergic receptor; D1ADR, human dopamine D(1A) receptor; D1BDR, human dopamine D(1B) receptor; D2DR, human dopamine D (2) receptor; D3DR, human dopamine D (3) receptor; ACM1, human muscarinic acetylcholine receptor M1; ACM2, human muscarinic acetylcholine receptor M1; ACM3, human muscarinic acetylcholine receptor M1; ACM4, human muscarinic acetylcholine receptor M1; ACM5, human muscarinic acetylcholine receptor M1; HH1R, human histamine H1 receptor; AA3R, human adenosine A3 receptor; AA2A, human adenosine A2a receptor; AA2B, human adenosine A2b receptor; ML1A, human melatonin type 1A receptor; ML1B, human melatonin type 1B receptor; ML1C, chicken melatonin type 1C receptor; OPSB, chicken blue-sensitive opsin; AT1BR, human angiotensin II type-1B receptor; AT1R, rat angiotensin II type-1A receptor; IL8A, human interleukin-8 receptor A; IL8B, human interleukin-8 receptor B; CKR6, human C-C chemokine receptor type 6; CKR3, human C-C chemokine receptor type 3; CKRA, human C-C chemokine receptor type 10; CXC-R5, human C-X-C chemokine receptor type 5; SS1R, human somatostatin receptor type 1; LSHR, human lutropin-choriogonadotropic hormone receptor precursor; TSHR, human thyrotropin receptor precursor; FSHR, human follicle stimulating hormone receptor precursor; GPR7, human neuropeptides B/W receptor type 1; GPR8, human neuropeptides B/W receptor type 2; HM74, human probable GPCR HM74; GPRX, mouse probable GPCR GPR33; GP72, mouse probable GPCR GPR72 precursor. NT: N-terminus; TM1-7: Transmembrane domain 1-7; CT: Carboxyl terminus.