Research Paper Volume 11, Issue 10 pp 3117—3137

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Figure 10. Inflammation elevated in aging zebrafish retina and not regulated by resveratrol treatment (A) Representative western blot showing the protein expression level of iNOS in young, resveratrol-treated young, aging, and resveratrol-treated aging zebrafish retinas. (B) The densitometric mean and SEM of bands from A normalized to the corresponding level of the loading control protein beta-tubulin (**P<0.01, n=3). (C-E) Cox-2, TNF-α, and IL-1β expression in young, resveratrol-treated young, aging, and resveratrol-treated aging zebrafish retinas. Graphs represent (C) Cox-2, (D) TNF-α, and (E) IL-1β gene expression by quantitative real-time PCR (mean ± SEM, *P<0.05 **P<0.01, n=3). young, 4-6 month old zebrafish; young + RES, young zebrafish after resveratrol treatment for 10 day; aging, 19-23 month old zebrafish; aging + RES, aging zebrafish after resveratrol treatment for 10 days.