Research Paper Volume 11, Issue 10 pp 3117—3137

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina

Figure 9. Resveratrol treatment activated the antioxidant system and Ampk/Sirt1/Pgc1α pathway in aging zebrafish retina. (A-F) Cu/Zn-Sod, Mn-Sod, Gpx, Ampk, Sirt1, and Pgc1α expression in young, resveratrol-treated young, aging, and resveratrol-treated aging zebrafish retinas. Graphs represent (A) Cu/Zn-Sod, (B) Mn-Sod, (C) Gpx, (D) Ampk, (E) Sirt1, and (F) Pgc1α gene expression by quantitative real-time PCR (mean ± SEM, *P<0.05 **P<0.01 ***P<0.001 ****P<0.0001,#P means no statistical significance, n=3). young, 4-6 month old zebrafish; young + RES, young zebrafish after resveratrol treatment for 10 days; aging, 19-23 month old zebrafish; aging + RES, aging zebrafish after resveratrol treatment for 10 days.