Research Paper Volume 11, Issue 10 pp 3280—3297

Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease

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Figure 1. Deletion of NRSF in the brain exacerbates motor defects induced by MPTP. (AD) Behavioral assays at 7 days after saline or MPTP administration. (A, B) Pole test results. (A) Time to turn. (B) Total time. N = 18-21. (C, D) Wire hanging test results. (C) Latency time. (D) Score. N = 16-19. (EH) Behavioral assays at 42 days after saline or MPTP administration. (E, F) Pole test results. (E) Time to turn. (F) Total time. N = 9-12. (G, H) Wire hanging test results. (G) Latency time. (H) Score. N = 9-11. All data are means ± SEM. Differences were analyzed by one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, vs saline-treated control; #p < 0.05, ### p < 0.001, vs MPTP-treated WT mice.