Research Paper Volume 11, Issue 10 pp 3280—3297

Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease

Figure 1. Deletion of NRSF in the brain exacerbates motor defects induced by MPTP. (AD) Behavioral assays at 7 days after saline or MPTP administration. (A, B) Pole test results. (A) Time to turn. (B) Total time. N = 18-21. (C, D) Wire hanging test results. (C) Latency time. (D) Score. N = 16-19. (EH) Behavioral assays at 42 days after saline or MPTP administration. (E, F) Pole test results. (E) Time to turn. (F) Total time. N = 9-12. (G, H) Wire hanging test results. (G) Latency time. (H) Score. N = 9-11. All data are means ± SEM. Differences were analyzed by one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, vs saline-treated control; #p < 0.05, ### p < 0.001, vs MPTP-treated WT mice.