Research Paper Volume 11, Issue 10 pp 3280—3297

Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease

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Figure 6. Early assessment of neurogenesis. (A) Immunohistochemical staining of BrdU in the SVZ, 7 days after MPTP/saline treatment. Scale bar: 200 μm. Quantification of BrdU-positive cells is shown in the right panel. Data are means ± SEM. Data were analyzed by one-way ANOVA. **p < 0.01, vs saline-treated control; ##p < 0.01, vs MPTP-treated WT mice. N = 3–4. (BD) Immunofluorescence staining of BrdU (red) and Nestin, Sox2, or GFAP (green) in the SVZ. Scale bar: 100 μm.