Figure 3. Immunohistochemistry of GFAP and Tau in the brain. (A-F) The quantification and representative images of the immunohistochemistry for positive cells per field of view for (A-C) doublecortin, (D-E) glial fibrillary acidic protein (GFAP), and (F) p-Tau(Ser396) in brain regions such as the hippocampus, dentate gyrus, and the neocortex. The data is shown for young and old wild-type and G3 Tert-/- mice. Data represent the mean ±SE of analyzed mice within each group. For the histopathology results, the number of mice analyzed per group is indicated, as well as the number of fields of view, and the number of positive cells. The t-test was used for statistical analysis. *p<0.05; **p<0.01; ***p<0.001.