Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 6. Down-regulation of vascular angptl2 is senolytic and anti-atherogenic. (A) Decrease of mRNA expression of the indicated genes in the native aortic endothelium isolated from AAV1-shAngptl2-treated ATX mice, 3 months post-infection. Data are mean±SEM of n mice. *: p<0.05; **: p<0.01; ***: p<0.001 vs. shSCR group. (B) Decrease of mRNA expression (except for p21) in the de-endothelialized aortic wall (media) isolated from AAV1-shAngptl2-treated ATX mice, 3 months post-infection. Data are mean±SEM. *: p<0.05 and **p<0.01 vs. shSCR group.