Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 7. Down-regulation of vascular angptl2 is senolytic by promoting apopotosis. (A) Induction of Angptl2+ senescent endothelial cells apoptosis 1-week post-injection of AAV1-shAngptl2 in aortas of ATX mice: Bax mRNA expression increased (left, p=0.005) while Bcl2 mRNA expression decreased (middle, p=0.003), increasing Bax/Bcl2 ratio (right). (B) Absence of apoptosis in cells from the media 1-week post-injection of AAV1-shAngptl2 in aortas of ATX mice. Data are mean±SEM of n ATX mice.