Research Paper Volume 11, Issue 12 pp 3919—3938

Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging

Figure 4. Accelerated follicle depletion in Mfn2-/- mice. (A, C, E, G) Representative micrographs of 3-weeks and 2-, 6- and 12-months old Mfn2-/- and WT mice ovary sections stained with hematoxylin and eosin. (B, D, F, H) Follicle counts in 3-weeks and 2-, 6- and 12-months old Mfn2-/- and WT mice ovaries. Data presented as mean ± SEM. *p < 0.05 vs. WT using t-test.