Research Paper Volume 11, Issue 12 pp 4183—4197

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Figure 5. AKG inhibits the Warburg effect and activates JNK signaling. (A) Relative mRNA expression of downstream and upstream genes involved in the Warburg effect (ns = nonsignificant, p > 0.05; *p < 0.05 and **p < 0.01; two-tailed Student’s t-test). (B) Relative mRNA expression of downstream and upstream genes in the JNK signaling pathway (*p < 0.05 and **p < 0.01, two-tailed Student’s t-test).