Research Paper Volume 11, Issue 19 pp 8068—8084

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888

Figure 3. Circ-APC significantly increases APC expression in DLBCL. (A and B) qRT-PCR and Western blot analyses of APC expression in control or stably circ-APC-overexpressing U2932 and TMD8 cells. (C and D) qRT-PCR and Western blot analyses of APC expression in the subcutaneous tumors of nude mice injected with control or stably circ-APC-overexpressing U2932 cells. (E) The correlation between circ-APC and APC expression in the above subcutaneous tumors. (F) Cell proliferation rate in stably circ-APC-overexpressing U2932 and TMD8 cells transfected with si-APC. **p < 0.01, ***p < 0.001.