Research Paper Volume 11, Issue 19 pp 8068—8084

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888

Figure 6. Circ-APC dampens canonical Wnt/β-catenin signaling in DLBCL. (A) TOPFlash/FOPFlash reporter assay in stably circ-APC-overexpressing U2932 and TMD8 cells transfected with miR-888 mimics or si-TET1. (B and C) Western blot analysis of the indicated proteins in stably circ-APC-overexpressing U2932 and TMD8 cells transfected with miR-888 mimics or si-TET1. (D) Schematic diagram of circ-APC inhibiting proliferation through the miR-888/APC and TET1/APC axes in DLBCL cells. *p < 0.05, **p < 0.01.