Research Paper Volume 11, Issue 16 pp 5924—5942

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus

Figure 5. Heart failure (HF) rats showed consolidation memory decline. (A) Representative cartoon showing the rat and platform position in the pool. (B) Representative trajectory heat maps obtained from one Sham rat and one HF rat during Water Maze test during day 9 and 10. Contrary to day 9, in day 10 the platform was removed. Pseudocolor intensity indicate the time latency that the rat remained swimming and searching for the platform. Contrarily to Sham rats, HF animals showed less persistence in the place where the platform was originally located. (C) Summary data showing latency to first entry to the place where the platform was located (day 9). (D) Summary data showing the distance for first entry to the place where the platform was located (day 9). HF rats travelled more distance to first entry compared to Sham animals. (E, F) HF rats display a significant decrease in the time and entries to the place where the platform was located (compared to day 9). Values are means ± S.E.M. *, p<0.05, Unpaired t-test. n=6 rats per group.