Research Paper Volume 11, Issue 16 pp 5924—5942

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus

Figure 7. Memory flexibility at day 3 was compromised in heart failure (HF) rats. (A) Representative cartoon showing the rat and platform position at day 3. (B) Representative trajectory maps obtained from one Sham rat and one HF rat during day 3 of memory flexibility test. (C) Summary data showing average paths efficiency in each trial during day 3 of testing in Sham (white circle) and HF (black circle) rats. (D) Summary data showing average latencies from each trial during day 3 in Sham (white circle) and HF (black circle) rats. (E, F) Summary data of average paths efficiency and latencies at trial four (n=6 per group). Note that HF rats display an increase in the number of trials needed to complete the test, as well as an increase in the duration of each trial. Values are means ± S.E.M. *, p<0.05 vs. Sham, Unpaired t-test. n=6 rats per group.