Research Paper Volume 11, Issue 16 pp 5992—6013

LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts

Figure 5. Reciprocal repression of RP11-670E13.6 and miR-663a. (A) miR-663a negatively regulated the expression of its target gene RP11-670E13.6. (B) RP11-670E13.6 negatively regulated the expression of miR-663a. (C) Putative binding site of miR-663a in RP11-670E13.6 and the site of target mutagenesis are indicated. (D) Luciferase activity in HDFs, demonstrating the effects of miR-663a on the expression of its target gene RP11-670E13.6. Data are shown as the means ± standard errors of the means based on at least three independent experiments. P values were determined by Student’s t-tests. *P < 0.05; **P < 0.01; and ***P < 0.001.