Research Paper Volume 11, Issue 16 pp 6053—6068

LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma

Figure 5. NEDD4-1 reversed LINC01198-induced glioma proliferation and resistance to temozolomide. (A) Forced LINC01198 expression did not increase cell proliferation in NEDD4-1-knockout glioma cells. (B) Forced LINC01198 expression did not promote resistance to temozolomide in NEDD4-1-knockout glioma cells. (C) Reduced LINC01198 expression did not inhibit cell proliferation in NEDD4-1-knockout glioma cells. (D) Reduced LINC01198 expression did not inhibit resistance to temozolomide in NEDD4-1-knockout glioma cells. (E) PTEN expression in LINC01198-overexpressing glioma cells was modified by cDNA transfection. (F) recovered PTEN expression reversed LINC01198-induced tumor growth in glioma. Data are presented as the mean±S.D, n=3.