Research Paper Volume 11, Issue 16 pp 5895—5923

DNA methylation-based estimator of telomere length

Figure 6. Application of DNAmTL on in vitro keratinocytes, neonatal fibroblasts and adult coronary artery endothelial cells. Panel (A) depicts decreasing DNAmTL values of keratinocytes from five heathy donors as a function of cumulative population doubling (y-axis, in units in kilobase). Panel (B) show that DNAmTL values of neonatal fibroblasts are smaller than those of adult coronary artery endothelial cells (EC). Both cell types exhibit decreasing DNAmTL in function of cumulative population doubling (x-axis). Panel (C) is the average telomere length measurement of neonatal fibroblasts and adult endothelial cells, which revealed that the telomeres of the former are longer than those of the latter.