Figure 4. The amplitude and frequency of STOCs are lower in HFD DSM cells than in ND DSM cells. Representative STOC recordings in ND and HFD DSM cells at −40 mV. (A) and 0 mV (B). (C) The differences in the mean STOC amplitudes of ND and HFD DSM cells at −40 mV and 0 mV. (D) Comparison of the average STOC frequency in ND and HFD DSM cells at −40 mV and 0 mV. Data are expressed as the mean ± SEM; n = 14, N = 7 in the ND group, n = 14, N = 6 in the HFD group; * P < 0.05 for ND vs. HFD. ND: normal diet; HFD: high-fat diet; STOC: spontaneous transient outward current; NS: not significant.