Figure 7. Hyperpolarization of the membrane potential upon pharmacological activation of BK channels is attenuated in HFD DSM cells. Representative recordings in current-clamp mode illustrating the NS1619 (30 μM)-induced hyperpolarization effect on the membrane potential in ND (A) and HFD (B) DSM cells. (C) Summary data indicating a significantly attenuated hyperpolarization effect on the membrane potential in HFD DSM cells compared with ND DSM cells. Data are expressed as the mean ± SEM; n = 8, N = 6 per group; * P < 0.05 for ND vs. HFD; # P < 0.05 for control vs. NS1619. ND: normal diet; HFD: high-fat diet; NS: not significant.