Research Paper Volume 11, Issue 16 pp 6273—6285

Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma

Figure 7. Kindlin-2 is overexpressed in melanoma, and elevated kindlin-2 predicts a poor prognosis. (A) The protein levels of kindlin-2 in 16 pairs of melanoma and matched peri-tumour tissues. (B) The mRNA levels of kindlin-2 in 16 pairs of melanoma and matched peri-tumour tissues. (C) Representative images of the TMA after H&E staining and IHC staining with the kindlin-2 antibody. (D) The kindlin-2 expression levels in melanoma and peritumoural tissues were analysed by average densitometry. (E and F) The kindlin-2 levels in different groups were analyzed according to the Clark level and clinical stage. (G) Overall survival analysis of 197 melanoma patients according to the expression of kindlin-2. *p<0.05, ****p<0.0001. T, tumour; P, peritumour.