Research Paper Volume 11, Issue 16 pp 6358—6370

Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation

Figure 5. The plasma content of VWF and PDI was detected and the activity of platelet between the four groups was compared. (A) The VWF content in the plasma was detected using ELISA; (B) The PDI content in the plasma was detected using ELISA; (C) Flow cytometry was used to detect activated GP IIb/IIIa on the platelet surface; (D) Flow cytometry was used to detect P-selectin expression on the platelet surface *P < 0.05, **P < 0.01, ***P < 0.001, versus Chow; #P < 0.05, ##P < 0.01, ###P < 0.001, versus Chow + Rutin, P < 0.05, ††P < 0.01, P < 0.001, versus DM. Chow, normal group; Chow + Rutin, normal diet plus rutin; DM, Diabetic group; DM + Rutin, diabetic group plus rutin (n = 3–8). Data were analyzed using one-way ANOVA.