Research Paper Volume 11, Issue 16 pp 6503—6521

Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma

Figure 7. Functions enrichment and signaling pathways analysis of the mutations in PLODs and their 45 frequently altered neighbor genes in ccRCC patients. (A) Network of PLODs and their 45 frequently altered neighbor genes was constructed using cBioPortal. (B) The functional annotation analysis of PLOD1/2/3 was constructed using ClueGO, a plug-in of Cytoscape. Corrected p-value <0.01 was considered statistically significant. (C) Functional and pathway enrichment analyses of PLOD1/2/3 were performed using DAVID and visualized in bubble chart. (D) Functional and pathway enrichment analyses of 48 involved genes were performed using DAVID and visualized in bubble chart.