Research Paper Volume 11, Issue 19 pp 8139—8155

Hypermethylated long noncoding RNA MEG3 promotes the progression of gastric cancer

Figure 4. Restored expression of MEG3 inhibits the development of gastric cancer cells. (A) The number of clones was significantly reduced in the lncRNA MEG3-overexpressing group and the 5-Aza group compared with the NC group. *P<0.05, **P<0.01, compared with the NC group. #P<0.05, compared with the 5-Aza group. (B) The apoptosis rate of MGC-803 cells transfected with MEG3 or 5-Aza dramatically increased compared with the NC group. *P<0.05, **P<0.01, compared with the NC group. #P<0.05, compared with the 5-Aza group. (CD) Wound healing and transwell assays showed significantly reduced cell migration and invasion ability in the MEG3 and 5-Aza groups compared to the control group. *P<0.05, **P<0.01, compared with the NC group. #P<0.05, compared with the 5-Aza group.