Research Paper Volume 11, Issue 19 pp 8183—8203

CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression

Figure 3. Effects of circRNA Cdr1as in HCC cells are reversed by miR-1270 to some extent. (A) Relative expression of miR-1270 in circRNA Cdr1as-repressed HepG2 cells treated with miR-1270/NC inhibitor through qRT-PCR. (B) Relative expression of miR-1270 in circRNA Cdr1as-overexpressed SMMC-7721 cells treated with miR-1270/NC mimics through qRT-PCR. (C, E) Cell proliferation capacities of circRNA Cdr1as-repressed HepG2 cells with or without suppression of miR-1270 are analyzed. (D, F) Cell proliferation capacities of circRNA Cdr1as-overexpressed SMMC-7721 cells with or without upregulation of miR-1270 are analyzed. (G) Cell migration capacities of circRNA Cdr1as-repressed HepG2 cells with or without suppression of miR-1270 are analyzed. (H) Cell migration capacities of circRNA Cdr1as-overexpressed SMMC-7721 cells with or without upregulation of miR-1270 are analyzed. Data are the mean ± SEM. *P<0.05, **P<0.01, ***P<0.001.