Research Paper Volume 11, Issue 19 pp 8329—8346

Involvement of adiponectin in age-related increases in tear production in mice

Figure 1. Pilocarpine-stimulated tear secretion increased in aged mice, but not in high-fat diet-fed mice. (A and B) Body weights and the weights of the lacrimal glands (LG) in young, middle-aged, and aged mice. Upper and lower graphs show male (N=5) and female mice (N=4-6), respectively. (CE) Absolute volume of tear flow ©, adjusted by body weight (D) or LG weight (E). Upper and lower graphs show male (N=6) and female mice (N=4-6), respectively. (F) Body weight in normal diet (ND)- or high-fat diet (HFD)-fed mice for the indicated period (N=4). Upper and lower graphs show male and female mice, respectively. (G and H) Absolute volume of tear flow (G) adjusted by body weight (H) in ND or HFD-fed mice for the indicated period (N=4). Upper and lower graphs show male and female mice, respectively. Values are presented as means ± SEM. *p<0.05 and **p<0.01 (an unpaired Student’s t-test). #p<0.05 and ##p<0.01 versus young mice (Dunnett’s multiple comparison test).