Research Paper Volume 11, Issue 19 pp 8587—8603

A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment

Figure 6. Lack of VDR expression is associated with the sensitivity of chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors. (A) Venny diagrams depicted the common genes associated with chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors sensitivity. (B) Box plots showed the VDR expression in chemotherapy, BRAF inhibitors, PI3K-mTOR inhibitors sensitive and resistant colon cancer cells. (C) Box plots showed the VDR expression in each sub-cluster of colon cancer cells. (D) Relationships of VDR expression and disease free survival or overall survival were analyzed from GSE24551 and GSE39582 datasets.