Research Paper Volume 11, Issue 23 pp 10814—10825

Long noncoding RNA LINC00958 accelerates the proliferation and matrix degradation of the nucleus pulposus by regulating miR-203/SMAD3

Figure 5. Overexpression of LINC00958 inhibited aggrecan and Col II expression and promoted MMP-2 and MMP-13 expression. (A) The expression of MMP-2 was determined by using qRT-PCR analysis. (B) The expression of MMP-2 was determined by using qRT-PCR analysis. (C) Elevated expression of LINC00958 suppressed Col II expression in the NP cells. (D) Overexpression of LINC00958 inhibited aggrecan expression in the NP cells. GAPDH was used as the internal control. Data were showed as mean±SD.