Research Paper Volume 11, Issue 22 pp 10454—10467

Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db/db mice

Figure 1. Comparisons of metabolic parameters and gut microbiota profiles in db/db and m/m mice. (A) Blood glucose (t10 = 4.762, P < 0.001); (B) water intake (t10 = 9.981, P < 0.001); (C) food intake (t10 = 7.851, P < 0.001); (D) body weight (t10 = 20.41, P < 0.001); (E) Ace index (t10 = 2.823, P < 0.05); (F) Shannon index (t10 = 0.6029, P > 0.05); (G) unweighted UniFrac diversity distance; (H) PCA analysis of gut bacteria (PC1 versus PC2); (I) PLS-DA analysis of the data of gut bacteria. Data are shown as mean ± SEM values (n=6). *P < 0.05, **P < 0.01, ***P < 0.001. NS, not significant; PCA, principal component analysis; PLS-DA, partial least squares-discriminant analysis; SEM, standard error of the mean.