Research Paper Volume 11, Issue 22 pp 10499—10512

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

Figure 1. Effects of gradient concentrations of melatonin or IL-1β on the viability of NPCs for 24h detected by CCK-8 assay. (A) 0, 50, 100, 150, 200, 250, 500, 1000, 1500, 2000 μM melatonin treated NPCs for 24h (n=4). (B) 0, 1, 2.5, 5, 10 nM IL-1β treated NPCs for 24h (n=4). The values are expressed as mean ± SD. *P<0.05 vs control group; **P<0.001 vs control group.