Research Paper Volume 11, Issue 22 pp 10664—10683

Competing endogenous network analysis identifies lncRNA Meg3 activates inflammatory damage in UVB induced murine skin lesion by sponging miR-93-5p/epiregulin axis

Figure 7. Meg3 siRNA alleviates UVB-induced skin lesions in a mouse model. (A) Measurement of average erythema score of the murine dorsal skin with or without UVB irradiation. Values presented as mean ± SD. (B) Relative expression levels of Meg3, miR-93-5p and Ereg were determined by qRT-PCR. (C) H&E staining of the murine dorsal skin sample after UVB irradiation with or without si-Meg3 treatment (scale bar = 100 μm). (D) FISH of Meg3 in the murine dorsal skin sample after UVB irradiation with or without si-Meg3 treatment (scale bar = 100 μm).