Research Paper Volume 11, Issue 23 pp 10902—10922

The long non-coding RNA SNHG12 promotes gastric cancer by activating the phosphatidylinositol 3-kinase/AKT pathway

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Figure 3. SNHG12 promotes the migration and invasion of GC cells. (A, B) Wound healing and Transwell migration assays were performed to evaluate the migration abilities of AGS and MGC-803 cells transfected with si-SNHG12, and of BGC-823 cells transfected with pc-SNHG12. (C) A Transwell invasion assay was conducted to estimate the invasion abilities of AGS and MGC-803 cells transfected with si-SNHG12, and of BGC-823 cells transfected with pc-SNHG12. The migratory and invasive cells were stained with Hoechst. Data are shown as the mean ± SEM of at least three experiments. *P<0.05, **P<0.01, ***P<0.001.