Research Paper Volume 11, Issue 23 pp 10923—10938

Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice

Figure 1. KA augments inflammasome activity and tau phosphorylation in vivo and in vitro. (A, B) Truncation of GSK3β, phosphorylation levels of NF-κB, and the expression levels of NLRP3 and IL-1β as well as the phosphorylation of tau in the KA-treated mouse brain at different time points. (C, D) Truncation of GSK3β, phosphorylation levels of NF-κB, and the expression levels of NLRP3 and IL-1β as well as the phosphorylation of tau in KA-treated mixed cells. The optical density of bands in western blots was analyzed by Image J software (*P < 0.05, **P < 0.01, ***P < 0.001 vs. controls; the significant differences from the respective values were determined by one-way analysis of variance test. N = 3 for western blotting).