Research Paper Volume 11, Issue 23 pp 11391—11415

Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-κB pathway

Figure 4. MMP-9-induced BBB permeability is inhibited by melatonin. The value of the fluorescence that passed through the inserts was determined at 0, 5, 15, 30, 60, 90 and 120 min. Results are presented as the mean ± SD, n = 3. *p < 0.01 compared with the control; #p < 0.01 compared with the IL-1β-treated group; ##p < 0.01 compared with the IL-1β + DAPT group; $p < 0.01 compared with the IL-1β + PDTC group; &p < 0.01 compared with the IL-1β + SB-3CT group.