Research Paper Volume 12, Issue 1 pp 70—79

MACC1-AS1 promotes hepatocellular carcinoma cell invasion and proliferation by regulating PAX8

Figure 4. Elevated MACC1-AS1 expression promoted HCC cell epithelial-mesenchymal transition and invasion. (A) Ectopic MACC1-AS1 expression promoted vimentin, N-cadherin and snail expression and inhibited E-cadherin expression in SMMC7721 cell. (B) The mRNA expression of vimentin, N-cadherin, snail and E-cadherin was detected by qRT-PCR. (C) MACC1-AS1 overexpression induced the cell invasion in SMMC7721 cell. (D) The relative number of invasive cells is shown. (E) MACC1-AS1 overexpression induced the cell invasion in MHCC-97H cell. (F) The relative number of invasive cells is shown. ***p<0.001.