Research Paper Volume 12, Issue 1 pp 260—287

CircNF1-419 improves the gut microbiome structure and function in AD-like mice

Figure 2. (A) Differentially expressed circRNAs in the APP/PS1 double transgenic mice brain samples (fold change > 1.50, p < 0.05 vs normal C57 mice, n=3). (B) Differentially expressed mRNAs in the APP/PS1 double transgenic mice brain samples (fold change > 1.50, p < 0.05 vs normal C57 mice, n=3). (C) Rarefaction curves based on OTU. The structure at the (D) phylum and (E) genus levels. (F) Histopathological changes in the brain identified using H&E staining and biomarker expression of Tau and Aβ1-42 using immunohistochemical methods after fecal microbiota from six months APP/PS1 mice transplantated into 9 months old C57 mice, (n≥6).