Research Paper Volume 12, Issue 1 pp 543—570

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

Figure 8. Activation of α7 nAChRs increases the expression of PSD95 protein in the hippocampus of APP/PS1_DT mice. The expression of PSD95 protein in the hippocampus of the APP/PS1_DT mice at (A) 6-months and (F) 10-months old. The IOD of PSD95 in hippocampus (B) CA1 area, (C) CA2 area, (D) CA3 area and (E) CA4 area of 6-month-old APP/PS1_DT mice. The IOD of PSD95 in hippocampus (G) CA1 area, (H) CA2 area, (I) CA3 area and (J) CA4 area of 10-month-old APP/PS1_DT mice. Control, WT C57 mice injected with saline; WP, WT mice injected with PNU; APP/PS1, APP/PS1_DT mice injected with saline; and AP, APP/PS1_DT mice injected with PNU. Compared with the control group, the expression of PSD95 protein in the hippocampus of the APP/PS1_DT mice group was significantly decreased and was partially reversed by PNU. This result suggested that activation of α7 nAChR partially reversed the expression level of PSD95 protein in the hippocampus of APP/PS1_DT mice. Data are presented as the mean ± standard deviation. *P<0.05, **P<0.01 vs. control group; #P<0.05, ##P<0.01 vs. APP/PS1 group.