Research Paper Volume 12, Issue 1 pp 672—689

Up-regulation of microRNA-375 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson’s disease by inhibiting SP1

Figure 4. Expression of TH positive neurons in the substantia nigra of rats in each group (n = 12). (A) Immunohistochemical staining of TH in substantia nigra of rats in each group (× 400, the arrow indicates the TH positive neurons); (B) Number of TH positive cells in substantia nigra of rats in each group; * P < 0.05 vs the normal group; # P < 0.05 vs the mimics NC group; & P < 0.05 vs the miR-375 mimics group. The measurement data were expressed as mean ± standard deviation and ANOVA was used for the comparison among multiple groups. After ANOVA analysis, the Tukey’s post-hoc test was used for pairwise comparison.