Figure 4. Expression of TH positive neurons in the substantia nigra of rats in each group (n = 12). (A) Immunohistochemical staining of TH in substantia nigra of rats in each group (× 400, the arrow indicates the TH positive neurons); (B) Number of TH positive cells in substantia nigra of rats in each group; * P < 0.05 vs the normal group; # P < 0.05 vs the mimics NC group; & P < 0.05 vs the miR-375 mimics group. The measurement data were expressed as mean ± standard deviation and ANOVA was used for the comparison among multiple groups. After ANOVA analysis, the Tukey’s post-hoc test was used for pairwise comparison.