Research Paper Volume 12, Issue 6 pp 4711—4726

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

Figure 3. XIST knockdown restores sensitivity of NSCLC cells to DDP. (A, B) XIST expression levels analyzed by qPCR in normal or DDP-resistant NSCLC cells transfected with si-XIST or si-nc (control siRNA). (C) Cell proliferation analysis (MTT) results and quantification of DDP inhibition in A549 and H1299 cells. (D) Viability assay results for NSCLC cells treated with various concentrations of DDP. (E) Viability assay results for XIST-overexpressing A549/DDP and H1299/DDP cells treated with various concentrations of DDP. (F) Apoptosis analysis of XIST knockdown effects in NSCLC cells exposed to DDP. * < 0.05 vs si-nc group.