Research Paper Volume 12, Issue 6 pp 4711—4726

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

Figure 7. XIST silencing inhibits NSCLC growth in vivo. (A) A xenograft nude mouse model was established using A549 cells transfected with si-XIST, si-SMAD2, or their combination. (B) Tumor volume measurements. (C) Tumor weight measurements. (D) A xenograft nude mouse model was established using A549/DDP cells transfected with si-XIST and subjected to DDP treatment. (E) Tumor volume measurements. (F) Tumor weight measurements. (G) IHC analysis of the expression of apoptosis (cyto-c, bax, bcl-2, and caspase-3) and pyroptosis (NLRP3, caspase-1, IL-1b, and IL-18) markers in excised tumor samples. * < 0.05 vs control or si-nc group, # < 0.05 vs DDP or si-XIST group.