Research Paper Volume 12, Issue 2 pp 1577—1590

PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies

Figure 2. Kaplan-Meier (KM) curves for progression-free survival (PFS) probabilities. (A) KM curves for PFS probabilities stratified by wild-type (WT) and PIK3CA–KD mutations, PIK3CA–HD mutations, PIK3CA–OD mutations, and other PI3K/AKT pathway aberrations (P/A). (B) KM curves for PFS probabilities stratified by wild-type (WT) and PIK3CA–KD mutations, PIK3CA–OD mutations, and other PI3K/AKT pathway aberrations (P/A). (C) KM curves for PFS probabilities stratified stratified by wild-type (WT) and PIK3CA–HD mutations. (D) KM curves for PFS probabilities stratified stratified by PIK3CA–HD mutations and PIK3CA–KD mutations. (E) KM curves for PFS probabilities stratified by PIK3CA–HD mutations and PIK3CA–OD mutations. (F) KM curves for PFS probabilities stratified by PIK3CA–HD mutations and other PI3K/AKT pathway aberrations (P/A).