Research Paper Volume 12, Issue 3 pp 2226—2245

Aucubin exerts anti-osteoporotic effects by promoting osteoblast differentiation

Figure 1. AU protected MG63 cells against Dex damage. (A) AU reduced the apoptosis rate of MG63 cells caused by Dex after 24 h incubation. (B) AU suppressed the over-accumulation of ROS in MG63 cells caused by Dex after 24 h incubation. (C) AU inhibited the dissipation of MMP in MG63 cells caused by Dex. (D) AU enhanced the expression levels of Bcl-2, and reduced the expression levels of Bax and cleaved caspase-3 in MG63 cells exposed to Dex. The quantification data of the expression levels of Bcl2, casepase3 and Bax were normalized by corresponding GAPDH. Data are expressed as mean ± S.D. (n=6) and analyzed using a one-way ANOVA. # P<0.05 and ## P<0.01 vs. control cells, *P<0.05 and **P<0.01 vs. Dex-exposed cells.