Research Paper Volume 12, Issue 3 pp 2246—2260

The protein tyrosine kinase inhibitor, Genistein, delays intervertebral disc degeneration in rats by inhibiting the p38 pathway-mediated inflammatory response

Figure 5. Genistein inhibits degradation and inflammation of NPCs in vitro. (A) Protein expression of MMP-3, IL-1β, and TNF-α in NPCs treated with Genistein or SB203580. (B) Protein expression of NF-κB in NPCs treated with Genistein or SB203580. (C) Quantification of MMP-3 protein expression. *p<0.05 (D) Quantification of TNF-α protein expression. *p<0.05 (E) Quantification of IL-1β protein expression. *p<0.05 (F) Quantification of NF-κB protein expression. *p<0.05.