Research Paper Volume 12, Issue 3 pp 2393—2407

Abnormal overexpression of G9a in melanoma cells promotes cancer progression via upregulation of the Notch1 signaling pathway

Figure 5. NICD blocked the inhibition of proliferation and metastasis induced by UNC0642 in human melanoma cells. (A) the proliferation of M14 cells with the treatment of UNC0642 or both UNC0642 and NICD was detected by CCK8. (B) the proliferation of A375 cells with the treatment of UNC0642 or both UNC0642 and NICD was detected by CCK8. (C) the migration and invasion of M14 cells with the treatment of UNC0642 or both UNC0642 and NICD was detected by transwell. (D) the column diagram showed the migration cell number in M14 cells. (E) the column diagram showed the invasion cell number in M14 cells. (F) the migration and invasion of A375 cells with the treatment of UNC0642 or both UNC0642 and NICD was detected by transwell. (G) the column diagram showed the migration cell number in A375 cells. (H) the column diagram showed the invasion cell number in A375 cells. *P<0.05 vs. Con group; #P<0.05 vs. UNC0642 group.