Research Paper Volume 12, Issue 3 pp 2471—2484

Sepsis induced cognitive impairments by disrupting hippocampal parvalbumin interneuron-mediated inhibitory network via a D4-receptor mechanism

Figure 3. RO-10-5824 treatment reversed decreased GABAergic transmission in the CA1 after CLP. (A) Representative traces of mIPSCs in slices from sham + NS, CLP + NS, and CLP + RO-10-5824 rats. (B) CLP did not affect the amplitude of mIPSCs (n = 10 pyramidal cells from three rats in each group). (C) CLP induced a significantly decreased frequency of mIPSCs, which was prevented by RO-10-5824 treatment (n = 10 pyramidal cells from three rats in each group). (D-E) CLP significantly decreased the total number of PV synapses around the pyramidal neurons as compared with sham group, which was not affected by RO-10-5824 treatment (n = 15 pyramidal cells from three rats in each group). Data are shown as mean ± SD, *P < 0.05 vs sham + NS group; #P < 0.05 vs CLP + NS group, scale bar = 50 μm.