Figure 7. CircRNA-miRNA interaction network for differentially expressed circRNAs in isoproterenol- treated and untreated mice. (A) Red circles represent down-regulated circRNAs, green circles represent up-regulated circRNAs, and blue circles represent binding miRNAs. (B) mRNA level of ANF and miR-23a were determined in left ventricles after isoproterenol treatment. Iso: isoproterenol. (C) mRNA level of ANF and miR-23a were determined in cardiomyocytes infected with adenovirus circ-wwp1, the results are the mean±SEM of three independent experiments. ** indicates p < 0.01 compared with control.