Research Paper Volume 12, Issue 4 pp 3175—3189

Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice

Figure 4. Ligustilide ameliorates mitochondrial morphology in SAMP8 mice. (A) The levels of (B) Mfn1, (C) Mfn2, (D) P-DRP1, DRP1, (E) P-AMPK and AMPK were detected in the hippocampus. (F) The expression of ATP was detected in the hippocampus. Ligustilide 10 (10 mg/kg/d); Ligustilide 20 (20 mg/kg/d). Data represent mean ± SD (n = 20 per group). #p < 0.05, ##p < 0.01, ###p < 0.001 versus SAMR1; *p < 0.05, **p < 0.01, ***p < 0.001 versus SAMP8.