Research Paper Volume 12, Issue 4 pp 3249—3265

The IL1β-HER2-CLDN18/CLDN4 axis mediates lung barrier damage in ARDS

Figure 2. Expression of core gene IL-1β. (A) The differentially expressed genes were scored according to the degree of similarity between genes and genes. (B) IL-1β appeared in the four data sets of ARDS Significantly high expression. (C) ROC curve analysis indicated IL-1β can distinguish ARDS and control in the four data sets. (D) IL-1β was up-regulated in lung and whole blood. (E) The concentration of IL-1β in lung tissue in patients with ARDS was significantly elevated. (F) The concentration of IL-1β in lung tissue and bronchoalveolar lavage fluid in patients with ARDS was significantly elevated. #, P < 0.05.