Research Paper Volume 12, Issue 4 pp 3431—3450

Development and validation of a prognostic classifier based on HIF-1 signaling for hepatocellular carcinoma

Figure 6. The risk score was an independent prognostic predictor in the derivation cohort. Kaplan-Meier plot showed that patients at high-risk exhibited a significantly poorer overall survival compared with those at low-risk (A). RCS curve showed an increased risk for overall survival accompanied by corresponding higher risk score (B). Univariate and multivariate Cox regression model indicated that the risk score was an independent prognostic predictor for overall survival (C, D). Chi-square test showed the correlation between risk score and T stage and TNM stage (E). *, P<0.05; **, P<0.01.