Research Paper Volume 12, Issue 5 pp 4111—4123

Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p

Figure 6. Ectopic expression of miR-30a-5p suppressed cell growth, cell cycle progression, inflammation and ECM degradation. (A) Overexpression of miR-30a-5p decreased cell proliferation in chondrocytes. (B) Elevated expression of miR-30a-5p suppressed the cell cycle in chondrocytes. (C) IL-6 expression was downregulated in chondrocytes after miR-30a-5p treatment. (D) miR-30a-5p overexpression inhibited IL-10 expression in chondrocytes. (E) Ectopic expression of miR-30a-5p decreased MMP-2 expression in chondrocytes. (F) The expression level of MMP-3 was decreased in chondrocytes after miR-30a-5p treatment. (G) Elevated expression of miR-30a-5p suppressed MMP-13 expression. (H) The expression of type II collagen was measured by qRT-PCR assay. *p<0.05 and **p<0.01.